Summary: In an effort to improve stability and shelf life of a drug, the active ingredients in many therapeutics are typically mixed with a number of other inactive chemicals. The end result of this process, called formulation, is commonly a liquid solution or suspension. However, for certain drugs, which are prone to degradation or aggregation, […]
On-Demand Webinar Lyophilized Drug Product Development Read More »
Thursday, October 15, 2020 at 11am EDT| 8am PDT| 4pm BST| 5pm CEST Event Overview: Determining the polymorphism of a drug—the propensity of a molecule to crystallize in different crystalline arrangements, to form crystalline salts and/or non-salt cocrystals—allows for rational selection of the proper solid form/polymorph for further development. In this webcast, learn about the
Live Webcast: Understanding Polymorphism to De-Risk Drug Development Read More »
ON DEMAND WEBINAR: Pharmaceutical Development of Oligonucleotides Oligonucleotides are an emerging class of DNA and RNA therapeutics that address a number of unmet medical needs. As with many biopharmaceuticals, the complex structure of oligonucleotides makes their large-scale synthesis both challenging and imperfect. A number of impurities are generated during manufacturing, many of which are hard
ON DEMAND WEBINAR: Pharmaceutical Development of Oligonucleotides Read More »
Check out Nishan Shah, Ph.D’s publication in AAPS News Magazine! Read More…
ON DEMAND WEBINAR: Integrated CMC Development of Gene Therapies Therapeutics that manipulate gene expression are a rapidly growing segment of biopharmaceuticals that address unmet medical needs. However, gene therapies usually include both nucleic acid and protein components, exponentially increasing the complexity of the development tasks needed to meet the Chemistry, Manufacturing, and Control (CMC) requirements
ON DEMAND WEBINAR: Integrated CMC Development of Gene Therapies Read More »
Pace Life Sciences now has Microflow Imaging Technology in Boston! This microflow imaging (MFI) technology allows PLS to find stabilizing formulations by identifying common protein physical degredation pathways. We use other complimentary techniques (SEC, FFF and MALS) to look at chemical and physical stability of biotherapeutics. The continuous addition of new technologies keeps PLS at
Pace Life Sciences now has Microflow Imaging Technology in Boston! Read More »
Live Webcast: Gene Therapy Development: From Methods to GMP Testing Thursday, August 20, 2020 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST Event Overview: The molecular complexity, size, and higher-order structure of gene therapies create a unique challenge for pharmaceutical development. Discriminating, stage-appropriate, analytical and biophysical tools are key to fully
Live Webcast: Gene Therapy Development: From Methods to GMP Testing Read More »
We are one of the only CROs in New England with Wyatt’s AF4 in house. This instrument uses Field Flow Fractionation (FFF) to separate biomolecules based on size using lower pressures and without stationary column. The addition of new technologies keeps PLS at the front of early-phase development expertise with complex biomolecules. We have repeatedly
Pace Life Sciences Now Has Wyatt’s AF4 Technology In Boston Read More »
Check out Nishan Shah, Ph.D’s publication in AAPS News Magazine! Read More…
Summary: Antibody-drug conjugates (ADCs) are a novel class of drugs that combine the potency of small molecule drugs with the targeting capabilities of highly-specific antibodies. While there is a wide array of different biochemical methods used for making ADCs, each method can have a varying effect on the stability of these types of therapeutics. In
On-Demand Webinar on Novel ADC Conjugates Read More »