Purification Processes & UF/DF
Prepare your biologic for advancement with downstream ultra filtration (UF) and diafiltration (DF) purification processes. Whether your project requires a one-off buffer exchange to support early-stage formulation development or a full-scale process development endeavor intended for transfer to GMP facilities, our team prepares your manufacturing and fill finish processes to optimize your drug product formulation.
Purification Process Development
Uf/df Process Development
TFF process development is critical to determine compatible membranes and process conditions as well as ensure your platform is scalable to produce biotherapeutics in suitable yield and quality. Our development endeavors focus on a scalable process to define optimal conditions for TFF, including the optimization of transmembrane pressure (TMP), feed flowrate, permeate flux, buffer compositions, therapeutic concentration, exchanged diavolumes and surfactant addition.
Our team optimizes downstream material purification processing for development and characterization endeavors. We have the capabilities to purify proteins across a broad range of separation modes, including Protein A, SEC, IEX, and HIC.
Integrated Laboratory Services
When your team needs additional CDMO support, our scientists are ready. Our state-of-the-art facilities and highly trained experts add power to your project.