At Pace we offer small scale feasibility and cGMP pilot scale spray drying for drug bioavailability enhancement. Production of amorphous solid dispersions via spray drying is a commercially proven approach to boosting bioavailability for poorly soluble drugs. Pace can rapidly assess the feasibility of spray drying when traditional approaches are not sufficient.

Benefits of amorphous solid dispersion via spray drying

  • Physical stability studies
  • Lab and pilot scale capabilities for R&D and GMP processing
  • Capabilities to process amorphous solid dispersion intermediates into finished product
  • In-vitro solubility screening of amorphous solid dispersions
  • Solid state characterization of amorphous solid dispersions
  • Drastically increases dissolution rate and apparent drug solubility
  • Inhibits recrystallization on shelf storage and in vivo
  • Feasibility can be performed at gram scale making it suitable for early development
  • Proven commercial track record
Technique
Equipment
Model
Type
Spray Drying
Spray Dryer
Mobile Minor Closed Cycle
GEA
Spray Dryer
B-290/295/296
Buchi
Hot Melt Extrusion
Hot Melt Extruder
ZSE-18HP-e
Leistritz
Hot Melt Extruder
ZSE-16 attachment
Leistritz
Loss-in-weight powder feeders (x2)
K-CL-24-KT20
K-Tron
Micro Liquid Additive Injection System
Optos-Series
Eldex
Side Stuffer
LSB-17
Leistritz
Chill Roll Cooler-Conveyor
AL-0810
Leistritz
Air-Quench Cooling Take-off Unit
AL-06
Leistritz
Dual Drive Stainless Steel Micro Pelletizer
Model 25
Leistritz
Nanoparticles
High Efficiency Bead Mill
Dyno(R)-Mill ECM-AP 05
WAB US Corp.